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Simvastatin breast cancer

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#1 Simvastatin breast cancer

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Simvastatin breast cancer

According to a review published in Breast Cancer: Targets and Therapystatins may be a potential therapeutic option to improve outcomes for patients with breast cancer. Breast cancer treatment modalities include surgery, radiotherapy, chemotherapy, hormone therapy, targeted therapy, and immunotherapy; because these complicated treatment combinations can have highly toxic safety profiles, there is a need for novel and effective treatments. Statins have historically been used for the treatment of hypercholesterolemia and secondarily for cardiovascular benefits, but Simvastatin breast cancer have been associated with benefit in immunomodulation, bone marrow stimulation induction, organ transplant, and inhibition of cancer progression. There is conflicting data, however, not only regarding the efficacy of statins Simvastatin breast cancer breast cancer recurrence and mortality but also for the statin type utilized eg, lipophilic vs hydrophilic. For this review, the authors present recent findings from vreast evaluating the effect of statins on clinical outcomes for patients with breast cancer and provide insight for potential future studies. Statins, or 3-hydroxymethylglutaryl-coenzyme A reductase inhibitors, are medications that have Simvastatin breast cancer used for decades to lower cholesterol and to prevent or treat cardiovascular diseases. Since their approval by the US Food and Drug Administration in the s, other potential uses for statins have been speculated on and explored. Basic science and clinical research suggest that statins are also effective in the management of breast cancer. Simvastatin breast cancer, in various breast cancer cell lines, statins increase apoptosis Wisconsin fair ass radiosensitivity, inhibit proliferation and invasion, Simvastagin decrease Simvastatin breast cancer metastatic dissemination of tumors. Clinical trials in Home excercise man boobs cancer patients support these laboratory findings by demonstrating improved local control and a mortality benefit for statin users. A role for statins in the management of aggressive breast Veronica mars erotica with poor outcomes — namely, inflammatory...

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Much preclinical and epidemiologic evidence supports anticancer effects of HMG-CoA reductase inhibitors statins. Epidemiologic evidence does not support an association between statin use and reduced breast cancer incidence , but does support a protective effect of statins—particularly simvastatin—on breast cancer prognosis. We argue that the current evidence base is sufficient to justify a clinical trial of breast cancer adjuvant therapy with statins. We advocate for such a trial to be initiated without delay. If a protective effect of statins on breast cancer recurrence is supported by trial evidence, then the indications for a safe, well-tolerated, and in expensive treatment can be expanded to improve outcomes for breast cancer survivors. We discuss several design opportunities—including candidate predictive biomarkers of statin safety and efficacy—and offer solutions to key challenges to enrolment, follow-up, and analysis of such a trial. Many in vitro and animal studies suggest that statin drugs suppress breast cancer progression. In human subjects, little evidence supports a protective effect of statins on breast cancer incidence , but consistent evidence supports a protective effect on disease recurrence. The case for adjuvant breast cancer therapy with statins is unlikely to be advanced by new observational epidemiology studies, so now requires evidence from a randomised trial. Our purposes herein are to provide a review of statin pharmacology, summarize the evidence for statin effects on breast cancer incidence and recurrence, describe why a clinical trial is the next necessary step, and evaluate key challenges and design opportunities germane to such a trial. Statins were discovered in with the isolation of mevastatin from Penicillium fungus. This prevents synthesis of cholesterol and two isoprenoids, farnesyl-PP and geranylgeranyl-PP, which post-translationally modify oncogenic proteins. Dashed arrows represent multi-step transitions. Partition constant; equal to the base 10 logarithm of the ratio of unionized solute concentration in octanol to unionized...

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Statins, or 3-hydroxymethylglutaryl-coenzyme A reductase inhibitors, are medications that have been used for decades to lower cholesterol and to prevent or treat cardiovascular diseases. Since their approval by the US Food and Drug Administration in the s, other potential uses for statins have been speculated on and explored. Basic science and clinical research suggest that statins are also effective in the management of breast cancer. Specifically, in various breast cancer cell lines, statins increase apoptosis and radiosensitivity, inhibit proliferation and invasion, and decrease the metastatic dissemination of tumors. Clinical trials in breast cancer patients support these laboratory findings by demonstrating improved local control and a mortality benefit for statin users. A role for statins in the management of aggressive breast cancers with poor outcomes — namely, inflammatory breast cancer and triple-negative breast cancer — is particularly implicated. However, data exist showing that statins may actually promote invasive breast disease after long-term use and thus should be prescribed cautiously. Furthermore, a general consensus on the type of statin that should be administered, for how long, and when in relation to time of diagnosis is lacking. Given their low toxicity profile, affordability, and ease of use, consideration of statins as a therapy for breast cancer patients is imminent. In this review, we summarize current evidence regarding statins and clinical breast cancer outcomes, as well as discuss potential future studies that could shed light on this increasingly relevant topic. Excluding dermatologic cancers, breast cancer is the most frequently diagnosed cancer among US women. Depending on the stage and histology of the cancer, patients may receive a combination or all of the following modalities: Although a comprehensive approach is often necessary in order to eradicate disease, breast cancer treatment protocols can sometimes prove too cumbersome, distressing, and even, at times, toxic for the patient...

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Simvastatin breast cancer

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Jun 2, - Statins may be good at delaying death from breast cancer, or they may help prevent death from the types of breast cancer that kill people early. Jan 5, - According to a review published in Breast Cancer: Targets and Therapy, statins may be a potential therapeutic option to improve outcomes for. Dec 8, - Statins may improve breast cancer outcomes whether women take them before or after their diagnosis and extend overall survival as well.

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